The PK/PD index for ciprofloxacin in critically ill patients
نویسندگان
چکیده
Introduction. The aim of the study was an analysis of pharmacokinetics and PK/PD parameters Cmax/MIC and AUC/MIC for ciprofloxacin in intensive care unit patients. Material and methods. Patients (n=3) received ciprofloxacin intravenously at 400 mg/ 8 h. Blood samples were collected on day 1st of the ciprofloxacin therapy. Plasma drug concentrations were measured by HPLC-UV method. Results. The mean maximum concentration after the first dose was Cmax = 3.26 (± 2.41) μg/ml. The mean Cmax/MIC and AUC/MIC ratio were: 10.48 (± 4.72) and 192.1 (± 134.8), respectively. Conclusions. Big inter-subject variability for PK/PD parameters in ICU patients requires systematic monitoring. AAnestezjologia i Ratownictwo 2010; 4: 409-413.
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